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However, its role in acetaminophen (APAP)-induced liver injury remains unclear

2022;9(22):e2201734

doi: 10.1371/journal.pone.0013545 85 ShearnCTSmathersRLStewartBJFritzKSGalliganJJHailNJr.et al

The reasons for edema are changes in BBB permeability induced by ischemia that result in a series of cytotoxic, ionic, and vasogenic edema events [73,74,75]