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venous blood vessels, and thereby does not tend to result in significant postural hypotension preferentially dilates arterioles Experimental studies indicate that its effect can be abolished by endothelial denudation, as well as pre-treatment with non-selective COX inhibitors or prostacyclin receptor antagonists, suggesting an endothelial-dependent mechanism involving COX-mediated formation of prostacyclin (Maille et al, 2016)

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Effect of a growth hormone-releasing factor antagonist on compensatory renal growth, insulin-like growth factor-I (IGF-I), and IGF-I receptor gene expression after unilateral nephrectomy in immature rats