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It is, therefore, evident that the therapeutic effects of tamoxifen cannot be explained entirely by its blockade of ER or other estrogen receptors, especially since much of the earlier clinical data was established before the identification of ER and GPR30

Acknowledgments This work was supported by grants from University of Padova, Neurofibromatosis Therapeutic Acceleration Program and Associazione Italiana Ricerca Cancro (AIRC grant IG 2017/20749)

How I try to mimic that is with resistance in blood flow, which restricts oxygen to the muscle, builds up lactate, now used as an energy source which we previously thought was a negative byproduct