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Mutually exclusive IDH1 or IDH2 mutations are common in myeloid malignancies and gliomas, and cause the production of 2-hydroxyglutarate (2HG), an oncometabolite that impairs -KGDD function by acting as a competitive inhibitor of -KG binding (Han et al., 2020)

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doi: 10.1006/geno.1997.4972 272 FilardoEJQuinnJASaboE