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Likewise, treatment of aortic SMCs with IL-1 or IL-6 caused a dose-dependent increase in alkaline phosphatase activity and increased cell mineralization in vitro (196)

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Conclusion: These promising findings advocate for the therapeutic potential of HepLPCs as an innovative strategy for liver cirrhosis, warranting further exploration through clinical trials, particularly in decompensated cirrhosis and acute-on-chronic liver failure patients