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Abbreviations PD: Parkinsons disease -Syn: -Synuclein ROS: Reactive oxygen species GSH: Glutathione GSH-Px: Glutathione peroxidase PUFA: Polyunsaturated fatty acid GPX4: Glutathione peroxidase 4 MDA: Malondialdehyde BJP-IVb: Buddlejasaponin IVb IRP2: Iron regulatory protein 2 GAA: Ganoderic acid A LC3B: Light chain 3B NCOA4: Nuclear Receptor Coactivator 4 FTH1: Ferritin heavy chain 1 DA: Dopamine BJP-IVb: Buddlejasaponin IVb LC3: Light chain 3 LDs: Lipid droplets FMT: Fecal microbiota transplantation Neo: Neoeriocitrin ASH: Acanthopanax senticosus TH: Tyrosine hydroxylase CA: Chicoric acid PPDs: Protopanaxadiols Cyt C: Cytochrome C Bax: Bcl-2-associated X protein SalB: Salvianolic acid B ERS: Endoplasmic reticulum stress CNS: Central nervous system BBB: Bloodbrain barrier IL-6: Interleukin-6 IL-10: Interleukin-10 TNF-: Tumor necrosis factor-alpha CSE: C

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[Abstract]2026 Apr 23;69(8):9603-9614

HYDROCODONE BITARTRATE AND ACETAMINOPHEN - hydrocodone bitartrate and acetaminophen tablet Eywa Pharma Inc ---------- WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF HYDRCODONE BITARTRATE AND ACETAMINOPHEN TABLETS Addiction, Abuse, and Misuse Because the use of Hydrocodone Bitartrate and Acetaminophen Tablets exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patients risk prior to prescribing and reassess all patients regularly for the development of these behaviors and conditions [see WARNINGS]

Regarding altered neuronal/synaptic activity, a reduced glutamatergic projection from ACC to the ventral hippocampal CA1 area is suggested to contribute to depressive-like symptoms in 3-month-old 5xFAD mice (Kim et al., 2023)