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RES and 3-(4-hydroxyphenyl)-propionic acid (4HPP), a microbial metabolite of RES, significantly reduced paracellular permeability and proinflammatory cytokine secretion in LPS-treated Caco-2 cells, correlating with increased TJ protein expression [409]

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As described in the FY 2023 IPPS/LTCH PPS final rule (87 FR 49144 through 49147), CMS waived certain Medicare rules for CAHs participating in the demonstration extension period to allow for alternative reasonable cost-based payment methods in the three distinct intervention service areas: telehealth services, ambulance services, and skilled nursing facility/nursing facility services

Because the final inflated average case-weighted standardized charge per case exceeded the average case-weighted threshold amount in both scenarios, the applicant asserted that TECVAYLI TM meets the cost criterion