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Simoes A, Chen L, Chen Z, Zhao Y, Gao S, Marucha PT, Dai Y, DiPietro LA, Zhou X

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(1S,3R)-RSL3, also known as RSL3 , and ML162 (also known as DPI7) can deactivate GPX4, triggering ferroptosis in cells ( 2.1.2 Ferroptosis and polyunsaturated fatty acids Ferroptosis is characterized by lipid peroxidation, a process regulated by the system xc/GPX4/GSH signaling pathway

Moreover, research should not only focus on the common types of high clinical incidence but should also be more comprehensive to explore the relationship between different subtypes of ovarian cancer and ferroptosis, to carry out mechanism-regulated therapeutic intervention more accurately