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Telomeres are the protective caps at the ends of chromosomes

Thus, the transcription and DNA replication are disturbed, leading to the induction of apoptosis

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Based on the careful analysis of the outputs of several biophysical tools, these authors have made a set of very important conclusions: good agreement between the ultracentrifuge and Sephadex experiments was obtained on the assumption that Sephadex chromatography depends on the effective hydrodynamic radii of proteins and not on their molecular weights