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doi: 10.1007/s00404-011-1968-9 189 UhlnMFagerbergLHallstrmBMLindskogCOksvoldPMardinogluAet al

These authors further speculate that the natural process of brain masculinization puts males at risk of ASD by moving them closer to a vulnerability threshold, breached by refractory inflammation during critical periods of brain development [574]

Since natural glutathione production also decreases, there's little defense against the increase in oxidative stress

Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H

There is no reason to suspect such phenomena are isolated to chronic disease and do not occur alongside or as a consequence of acute inflammatory events such as those which cause critical illness: The acute phase of critical illness is undoubtedly characterized by tremendous immune activation and consequential free radical mediated damage (53, 54)