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Additionally, cystamine and ornithine-threonine-cysteine (OTC), a cysteine prodrug, protect neurons from oxygenglucose deprivation (OGD)-induced death by increasing GSH levels in the penumbra after reperfusion, demonstrating neuroprotection (156)

177,178 Mutations in ZIP4 can lead to acrodermatitis enteropathica, a rare autosomal recessive metabolic disorder characterized by ZD, commonly observed in infants

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In addition, reduced creatine correlated with nonmodifiable factors, such as male sex and with altered renal function during the follow-up

Alfthan, G., Eurola, M., Ekholm, P., Venlinen, E