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therefore, deficient RBCs exhibit impaired antioxidant capacity and increased susceptibility to oxidative stress

Therefore, it is likely that FA-induced oxidative cytotoxicity might be more prevalent in blood-derived cells, which is consistent with the hematopoietic phenotypes reported in IBMFS/AMeD patients

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The use of stem cells has also been significant in providing an effective means of investigating and modeling key mechanisms involved in AD through over 60 in vitro and in vivo studies, most of which utilized iPSCs-derived neurons

Primary Handling Editor: Revati Dewal, in collaboration with the Nature Metabolism team