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10.1001/jamaneurol.2016.1924 283 YeX.ZhangH.LiQ.RenH.XuX.LiX

The ACSL4 inhibitor rosiglitazone improves kidney function in DKD mice and reduces the lipid peroxidation product and iron content, and these effects are correlated with attenuated ferroptosis (23)

Interestingly, while antagonism of YIL781 and TAK-779 did not interfere with this effect, the administration of AMD3100, a CXCR4 antagonist, markedly reduced the LC3 II-to-LC3 I ratio in DOX-treated muscle co-administered with GHRP-6, suggesting that CXCR4 signaling plays a crucial role in mediating autophagic responses [2]