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Int J Neuropsychopharmacol (2019) 22(12):76577

Mekle R, Mlynrik V, Gambarota G, Hergt M, Krueger G, Gruetter R

CB-1158 could block myeloid cell-mediated inhibition of T cell proliferation, increase the number of tumor-infiltrating CD8 + T cells and NK cells, and increase the expression of inflammatory factors and interferon-, thereby changing the immune microenvironment to promote inflammation and reduce tumor immune escape, inhibiting tumor cell proliferation