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To find out whether juglone has an affinity for any other binding site other than the glutathione binding site, we generated a slightly different model system, where glutathione was bound to ChaC1 protein at its binding site, and juglone was blindly docked to this system

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Furthermore, the association between NINJ1 and the xCT transporter, along with the availability of GSH and CoA, could also imply a potential mechanism underlying the tumor suppression function of NINJ1 in certain cancer types

A., Mortadza, S

DOI: 10.1016/j.immuni.2020.05.002 Gordon DE et al