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This leads to transcriptional repression of lipogenic regulatorsincluding sterol regulatory element-binding protein 1c (SREBP1c), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC)resulting in reduced hepatic steatosis, improved insulin sensitivity, and systemic metabolic restoration

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While we see a trend for cells with KRAS mutations to be less sensitive to serine and glycine starvation alone, exceptions are likely to reflect other changes that influence the serine synthesis pathway such as PHGDH amplification

10.1111/ijlh.12455 [DOI] [PubMed] [Google Scholar] 101.Warny M, Lausen B, Birgens H, Knabe N, Petersen J

Chitosan-based nanoparticles can be easily prepared and modified to change their charge and adhesion properties