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The results, tracked via proton magnetic resonance spectroscopy, were highly promising: the NAC supplementation successfully returned cortical glutathione, ventricular lactate, and oxidative stress levels back to normal, which correlated directly with a significant reduction in patient fatigue

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Six mice were randomly divided into 2 groups and injected into the tail vein with Ru(II)-OH and NP4, respectively, and 10 L of blood was collected from the tail tip at 5 min, 10 min, 20 min, 30 min, 1 h, 2 h, 4 h, 8 h, 12 h, 24 h, and 48 h

Luciferase activity was measured with the Dual Luciferase Assay System (Beyotime, Shanghai, China)

These findings underscore the importance of mitochondrial health in disc homeostasis and provide novel insights into precise strategies for treating age-related degenerative spinal diseases