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Takasato et al

Cancer cells have many strategies to stay alive, and Mcl-1 is an important factor for a lot of acute myeloid leukemias and lymphomas and some solid tissue cancers like breast cancers

Over-loss and muscle pooled SURMOUNT, BMI below 22 reached by about 7% (as early as week 12), toward about 15% by week 88 in the longest trial, clinical underweight under 0.4% (Almandoz 2026)