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Never use the large reconstitution syringe to draw doses

Ethics declarations Conflict of interest The authors declare no conflict of interest

This gradual titration helps minimise gastrointestinal side effects, which are the most commonly reported adverse reactions

used heparinase inhibitors and a heparinase-deficient mouse model to demonstrate the pathogenic role of heparanase activation in sepsis-induced respiratory distress (53), and a similar phenomenon was identified in a model of ischemic acute kidney injury (66, 67)