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Elevated levels of adenosine in certain brain regions, such as the cortex and basal forebrain, have been associated with prolonged wakefulness, while lower levels are observed during sleep recovery periods

LDN is an immune-modulator that decreases the number of TH1 cells and TH17 cells results in immunebalance with the regulation of cytokines release [36]

Serine synthesis via PHGDH is essential for heme production in endothelial cells

A large number of preclinical studies have shown that treating Alzheimers disease against the ferroptosis mechanism is an efficient method, which can significantly improve the success rate of treatment and reduce the burden on patients with Alzheimers disease

Cross-cancer comparisons reveal that although the SSP serves conserved functions in sustaining one-carbon unit supply and mediating therapeutic resistance across cancer types, the remarkable heterogeneity of its upstream regulatory mechanismsincluding Kras/FGFR3 mutations, MYC-mediated stemness maintenance, and m6A epigenetic modificationsdictates that therapeutic strategies must be precisely tailored