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CDNF exerts effects through direct binding to unfolded protein response (UPR) sensors PERK and IRE1, while its family member MANF primarily signals via IRE1 [81]

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For the 5-ASA suspension, 0.5% carboxymethyl cellulose sodium (CMC-Na) was used as a suspending agent to prepare a final concentration of 0.025 g/mL