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Genetic and pharmacological inhibition of SLC7A11 in CRC stem cells significantly attenuates their viability in vitro and in vivo in comparison to CRCs (123, 124)

doi: 10.1128/IAI.72.5.2976-2988.2004 221 Mata-EspinosaDAFrancisco-CruzAMarquina-CastilloBBarrios-PayanJRamos-EspinosaOBiniEIet al

A Phase 2 trial found IGF-1 levels plateaued at month 6 despite continued daily dosing, suggesting partial desensitization of the GH-IGF-1 axis under constant stimulation