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Based on this thinking the proposed protocol is q48h 5 pulses of 20 mg = 100 mg total

doi: 10.1080/00325481.2017.1249265 [PubMed] 28806160 Thom RP, Mock CK, Teslyar P

Estrogen is important because it is a master regulator of metabolism, brain health, cell division, bone strength, and many other functions in addition to reproduction.[15][16] Estrogen is a steroid hormone (also called estradiol or E2) secreted by the ovaries and adipose tissue and its secretion becomes irregular as early as the Late Reproductive Stage (LRS) (Reproductive: Late Stage) of life