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Rational design is not widely used, except for P5, PRG-RADA16, and RK81 QTY [97,130]

It remains to be further investigated, whether it is possible to avoid blunting of the inhibitory action by other types of inhibitors, by their combination or by combination of the diverse therapeutic modalities to efficiently limit propagation of tumor cells

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It may also support the gut-brain axis by influencing neurochemical pathways and promoting communication between the gastrointestinal tract and central nervous system (CNS)