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10.1016/j.cmet.2017.12.017 39 Garca-RuizI.de la TorreP.DazT.EstebanE.FernndezI.Muoz-YageT.et al (2002)

The neurological category for both sets of criteria includes psychiatric symptoms such as anxiety, post-traumatic stress disorder (PTSD), and depression, which are shown at increased rates among GW veterans since the war ended ( Gulf War Illness is hypothesized to be related to neurotoxic exposures during the GW, which may have caused central nervous system (CNS) dysregulation ( Research has demonstrated that each component of the neurotoxic triad, including glutamate excitotoxicity, oxidative stress, and neuroinflammation, have been implicated individually in the underlying pathophysiology of anxiety, PTSD, and depression (45)