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The phosphoinositide 3-kinase (PI3K)/AKT pathway mediates extracellular and intracellular signals that preserve the integrity of the immune system 10 , particularly in macrophages 8

& Obrien, P

Neuron 72:257268 Rosen DR, Siddique T, Patterson D et al (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis