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Pathogenesis A localized proliferation of hepatocytes phenotypically different from surrounding hepatocyte parenchyma

This is due to the fact that those of us with darker skin absorb less UV light from the sun, making Vitamin D synthesis more difficult, making Vitamin D supplementation even more important in these populations

Consistent with the biological changes, immunoblotting analysis showed the late induction of p-H2AX and H2AX [45], suppression of ataxia telangiectasia mutated (ATM) [46] and pS1981-ATM, pT68-Chk2 (checkpoint kinase 2 serine/threonine kinase) [47], rap1 interacting factor (RIF)1 [48], Cdc25C [49], and Cyclin D1, and the induction of p21, CDK1, pS133-Cyclin B1 and Cyclin B1 (Fig

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