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The adipose tissue responds to excess nutrients by increasing their uptake and storage in existing adipocytes or by expanding their number through adipogenesis [78]

doi: 10.1016/j.envpol.2017.04.051 586 TeutenE

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Leucine-, arginine-, and methionine-derived SAM can bind their sensors during high intracellular concentrations, thereby disrupting the interaction of the sensors with GATOR1/2, relieving the inhibition of GATOR complex, and activating mTORC1