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In this regard, the European Medicines Agency (EMA) has issued a relevant decree requiring that the production of clinically applied MSCs must comply with GMP to ensure the repeatability, effectiveness and safety of therapeutic products [107]

Structural and functional changes in the atria affect these physiological processes and contribute to the development of ACM (Figure 2)

The combination activates two separate points in the GH regulatory axis simultaneously, which is pharmacologically distinct from activating either point in isolation

Overall, ACNs, with their wide range of sources and low toxicity profile, provide a valuable scientific basis for the development of novel phytochemicals targeting MSDs