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Kova, Hamburg (2017)

Organization of the human hepatocyte growth factor-encoding gene

Synaptogenesis and Dendritic Spine Formation Independent of the specific HGF-binding biochemistry, Dihexa treatment of cultured rat hippocampal neurons was reported to increase dendritic spine density roughly three-fold over 5 days (approximately 41 spines per 50 um of dendrite with Dihexa versus 15 with vehicle), with newly formed spines containing normal synaptic machinery (VGLUT1, synapsin, PSD-95) and functional AMPA-receptor-mediated activity

Brief temperature excursions of a few hours are unlikely to cause significant degradation