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It may, however, reduce the likelihood that triglycerides will require a dose interruption

Siddhi et al

Nature 487 , 491495 (2012)

521 Elevated hepatic insulin/AKT signaling supports liver regeneration by driving the synthesis of proteins, lipids, and glycogen

The basis of the pathological change is the cells inability to prevent protein misfolding, to revert misfolded proteins to normal, or to eliminate misfolded proteins by degradation