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Protein Kinase C (PKC) activation and advanced glycosylation end products (AGEs) formation Fig

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

Anderson, C., Milne, G

A related study found that Sirtuin 3 (SIRT3), a typical NAD + -dependent mitochondrial protein deacetylase, plays an important role in ROS generation and cell death [89]