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In autoimmune conditions, curcumin (1025 M) ameliorates disease severity by suppressing pathogenic Th1/Th17 responses while enhancing the activity of regulatory T cells (Tregs) ( + T-cell function and inactivating the AKT/mTORC1/STAT3/PD-L1 axis ( + T-cell differentiation into CD4 + CD25+FOXP3+ Tregs (Figure 2)

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Randomized phase III study of canfosfamide in combination with pegylated liposomal doxorubicin compared with pegylated liposomal doxorubicin alone in platinum-resistant ovarian cancer

258,259 Under stress conditions, Trx is released into the extracellular space where it exerts a cytoprotective effect and cytokine-like activities

p53 Because of its role in cell cycle arrest, senescence, and apoptosis, as well as for its interesting role in metabolism, oxidative responses, and ferroptosis, p53 has long been an important focus of research