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PMC 1287919

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If these immune checkpoint receptors become upregulated, proliferating T cells can become unresponsive to stimulation, entering a state called T cell exhaustion, eventually succumbing to apoptosis (Figure 2) [83,84,85], in which checkpoint ligands like PD-1 interacts with PD-L1 expressed by human granulomas [86] leads to reduced T cell cytotoxicity, proliferation, and activation [87]

Second, perilipins are recognized by the heat-shock cognate protein HSPA8/Hsc70 and bind the lysosomal membrane receptor LAMPA2

Interestingly, caveolin-1 overexpression protected and caveolin-1 knockout aggravated hepatic steatosis in HFD-fed mice by affecting lipogenesis, which indicates regulatory functions of caveolin-1 other than lipid transport in the liver [24]