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Dialysis removes approximately 13% of Sitagliptin and 23% of Saxagliptin

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As stated in the CY 2025 PFS proposed rule (89 FR 61981), we considered the following factors in determining a method and process for providing the rebate information: meeting statutorily provided deadlines in section 1860D-14B(a) of the Act (for example, dates by which to provide the rebate amount owed to the manufacturer)

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Surrogate variables to correct for batch effects To account for potential batch effects , we performed surrogate variable analysis (SVA) based on the DNA methylation levels at all CpG sites located on chromosome 10 using the R/Bioconductor package sva [31]