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5.1 Anti-CHD effects of GA CHD, caused by coronary atherosclerosis, leads to myocardial ischemia and hypoxia due to lipid metabolism disorders, oxidative stress, and inflammation (Donia and Khamis, 2021

In contrast, in cancer cells with high SLC7A11 overexpression, drastic accumulation of intracellular cystine and other disulfide molecules under H 2 O 2 treatment overrides any beneficial effect of GSH and leads to redox system collapse and rapid cell death (Fig