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Transforming growth factor- (TGF-) is known to promote fibrosis and contribute to POF (Persani et al., 2011), and collagen content and fibroblast proliferation are significantly reduced, which is related to AMPK-mediated suppression of TGF- production after metformin administration (McCloskey et al., 2020)

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The daily L-tyrosine dosing requirement ranges up to 75,750 mg per day, Table 1

doi: 10.1177/026988110001400208 29 HuijgensP