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10.1371/journal.pone.0051765 PLoS One 58 JiaY.CongR.LiR.YangX.SunQ.ParviziN.et al (2012)

Vitamin B12 is an essential nutrient that is essential for keeping the bodys nerve and blood cells healthy, supporting brain function, and aiding in the production of DNA

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The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail