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College of Liberal Arts & Sciences Rory Groner, Shawnee, Kansas

The two work on different but complementary parts of cellular energy metabolism: NAD+ supports the NAD+/NADH ratio essential to mitochondrial function, and MOTS-c activates the AMPK pathway and regulates mitochondrial gene expression

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Specifically, further investigations are needed to identify which patient groups benefit from physical chest clearance, mucus-modulating treatments, and regimens such as inhaled corticosteroids, long-acting beta-agonists, anticholinergics, and anti-inflammatory and antiinfective treatments

Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins