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This strategy achieved a 41-fold increase in brain accumulation of 3D6-Fab, representing a promising platform for efficient delivery of therapeutic antibodies to the CNS for the treatment of neurological diseases

Bielmann A, Sambiagio N, Wehr N, Gerber-Lemaire S, Bochet CG, Curty C

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Especially, the detailed knowledge of the nanocarrier-transporter complex internalization and following sorting processes and exocytosis would enable rational design of nanocarriers capable of efficient transcytosis across the BBB by minimizing the lysosomal degradation of the nanocarrier in the endothelial cells