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In addition to damaging the airway, alveoli and pulmonary vessels, COPD also damages the circulatory system, nervous system, motor system and other systems, resulting in remarkable extrapulmonary adverse effects (Vanfleteren et al., 2016)

Current researches have devised strategies for the successful incorporation of curcumin into various nano-carriers to ameliorate its bioavailability, cell uptake, specificity, and effectiveness, but limited work has been done regarding its anti-PC activity, with most nanoformulations have not cleared the pre-clinical stages [118, 119]

Int J Biol MacromolDeubiquitinase USP45 stabilizes RTCB and DDX1, promoting tumorigenesis and chemoresistance

The study also demonstrated that L-carnitinebased products increased the ratio of hairs in the anagen (growth) phase to those in the telogen (shedding) phase

( d ) Acetyl-LC inhibits HDAC1/2 activities in vitro and in cultured cells