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Results Tubular ER is enriched in developing myelin and contacts the myelin membrane We initiated our investigation by characterizing the presence of ER in developing myelin, focusing on mice at postnatal day 14 (P14), a stage at which active myelination occurs

To this end, we employed a swine model with DM and CKD, and in a comprehensive approach, combined unbiased proteomic assessment of changes in myocardial signaling pathways with direct measurements of cardiac and coronary microvascular function in vivo, mitochondrial function ex vivo, and detailed histological and molecular assessment of myocardial fibrosis and oxidative stress

Bax, Bcl-2-associated X protein