how does glutathione s-transferase cause drug resistance in cancer cells

how does glutathione s-transferase cause drug resistance in cancer cells transferases: substrates, inihibitors and pro-drugs and neurodegenerative diseases System Xc −/GSH/GPX4 axis: An

Name: how does glutathione s-transferase cause drug resistance in cancer cells transferases: substrates, inihibitors and pro-drugs and neurodegenerative diseases System Xc −/GSH/GPX4 axis: An
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System Xc GSH GPX4 axis: An important antioxidant system for the ferroptosis in drug resistant solid tumor therapy PMC how does glutathione s transferase cause drug resistance in cancer cells Glutathione S transferase : a potential role antitumor therapy DDDT Mechanisms of tumor cell resistance Frontiers Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches Unveiling the mechanisms and challenges of cancer drug resistance Cell Communication and Signaling Springer Nature Link Frontiers Modulation of redox homeostasis: A strategy to overcome cancer drug resistance

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Soluble GSTs consist of two subunits (25 kDa), which are divided into two domains: the N-terminal / forming the G region and the -helical forming most of the H region, which is responsible for the binding of the electrophilic substrate