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Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase

This enzyme catalyzes the transfer of a methyl group donated by SAMe and, depending on the substrate, results in the formation of homovanillic acid, normetanephrine, and metanephrine

Folate is a cofactor in one-carbon metabolism and depletion of folate allows formic acid to accumulate, and then to be excreted in the urine (Dow and Green 2000)

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