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YX: Writing original draft

Blood (2017 ASH Annual Meeting Abstract) 130(151), 2017

Vegetarians, elderly people, those suffering from pernicious or megaloblastic anemia, atrophic gastritis, Celiac disease, Crohns disease or other types of inflammatory gastrointestinal disorders are at greater risk for B12 deficiency

Interestingly, this metabolic and immunological coupling offers a survival advantage to cancer cells, particularly in heterogeneous oxygen landscapes, where some regions remain normoxic while others are severely hypoxic