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El dato animal de Tomas 1993 Tomas 1993 (Long-R3-IGF-1) administr Long-R3-IGF-1 subcutneo a ratas en restriccin calrica y report: Aumento significativo de ganancia de peso vs ratas controles a dieta similar Retencin de nitrgeno indicando preservacin de masa magra Eficacia mayor que IGF-1 nativo a dosis equimolar (consistente con la potencia in vitro 3) El hallazgo es mecansticamente coherente : ms IGF-1 libre ms seal en IGF-1R ms anabolismo en msculo y otros tejidos receptivos

Analyzing circulating Tfr cells in patients with sarcoidosis showed that within the total CD45RACCR7+ central memory Treg population, the proportion of CXCR5+ Tregs was increased, whereas the percentage of thymic CXCR5+ Tregs did not significantly differ from that in the control group (174)

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doi: 10.1016/S0151-9638(12)70127-8 150 Rodrguez-ArmbulaATorres-lvarezBCorts-GarcaDFuentes-AhumadaCCastanedo-CzaresJP