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However, as the pathogenesis of AD is complex (it is derived from both genetic and epigenetic factors), mechanisms of action of AGE on the improvement of cognitive and memory loss are also very complex

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*Correspondence: Bindu Diana Paul [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The gut microbiota is correlated with intestinal motility, with the enrichment of certain microbes, such as Rumioncoccaceae, Eubacterium, Butyricimonas , and Bacteroidetes , during constipation and the depletion of Prevotella, Faecalibacterium , and Dialister during diarrhea [293, 294]