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NAD + is also involved in metabolic switching, or the Warburg effect, in which the main source of energy production is anaerobic glycolysis through fermentation of pyruvate to lactic acid, as opposed to mitochondrial oxidative phosphorylation 340

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The physiological functions of iron include participating in the mitochondrial respiratory chain and hemoglobin synthesis

Accordingly, dysregulation of the FeS clusters biogenesis, including decreased expression of NFS1, has also been described as being relevant in mechanisms of resistance to cancer therapy

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