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The slightly slower kinetics of NERNST oxidation compared to the Grx1-roGFP2 probe likely stem from NERNST relying on endogenous glutaredoxins in the yeast cytosol to catalyse the equilibration of its roGFP2 domain with the glutathione redox couple

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537,538 Both preclinical and clinical research supports the use of Pycnogenol for cognitive support