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In people with diagnosed vitamin B12 deficiency, treatment may help support normal bodily functions

Mice undergoing in vivo reprogramming were found to become depleted in B 12 and show signs of methionine starvation while supplementing reprogramming mice and cells with B 12 increased reprogramming efficiency, indicating a cell-intrinsic effect

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In fact in the US the Centers for Disease Control (CDC) and the Institute of Medicine recommend B12 supplements for everyone over 50 years old

This means it's often considered in broader metabolic health studies, where improving cellular function is a key outcome